Interneuron-specific gamma synchrony indexes uncertainty resolution

Our new paper in eLife shows that a subclass of fast spiking interneurons in prefrontal and anterior cingulate cortex gamma synchronizes when uncertainty about cues and outcomes is resolved. This finding was possible by classifying narrow spiking neurons into fast and non-fast spiking classes and correlating their firing and spike-LFP synchrony during processing of attention cues and reward outcomes in a reversal learning task. In prefrontal cortex the interneurons of the fast spiking subclass synchronized after cue onset during learning when there was uncertainty about the value of different stimuli. In anteiror cingulate cortex the same type of fast spiking interneuron class gamma synchronized after rewards were delivered, but only when the reward predictions errors were high during learning, i.e. when outcomes were uncertain. Computational modeling showed that the interneuron specific gamma synchrony could reflect a soft gating of competing excitatory inputs.
These findings are of fundamental importance for understanding cell type specific circuit functions and might be the first characterization of interneurons in the primate prefrontal cortices during higher cognitive learning performances. The paper can be downloaded
here.

Related News

New 3D-object type with controllable feature space published with open-sourced code

The lab has a new publication showcasing and describing details of Quaddles: A multidimensional 3D object set with parametrically-controlled and customizable features. Quaddles have 5+ feature dimensions, each with multiple possible feature values that can be parametrically morphed, making it possible to generate a near arbitrary number of unique objects. Thanks to Marcus and Milad […]

2017 E.W.R. Steacie Memorial Fellowship Award

What an honour and incredible acknowledgment of our research – Thilo received the 2017 E.W.R. Steacie Memorial Fellowship Award with five fellow scientists in Canada and across the Natural Sciences and Engineering. This is one of the most prestigious awards for young scientists in Canada, celebrating the critical role of fundamental, basic research for driving […]

Acetylcholine, Dopamine, and Glutamate measured in three brain areas with a new SPME-probe

Our new paper shows reliable Multi-Neuromodulator measurements in the awake nonhuman primate in prefrontal cortex, premotor cortex and the basal ganglia using a new chemical sensing probe. The probe uses principles of Solid-Phase-Microextraction and is a development by the SPME pioneer and collaborator Prof. Janusz Pawliszyn from the University of Waterloo. The paper can be […]