Acetylcholinergic Drug enhances attention at different dose as cognitive flexibility

Acetylcholinergic Drug enhances attention at different dose as cognitive flexibility
We tested how a cholinergic drug that is used to treat symptoms of dementia (donepezil, Arizept) affects cognitive abilities across multiple domains in monkeys. We found that donepezil showed stunning improvements of attentional filtering (less distraction) during visual search but at a different dose at it enhanced flexible learning of attention sets. See our paper Hassaniet al. (2023). Dose-dependent dissociation of pro-cognitive effects of donepezil on attention and cognitive flexibility in rhesus monkeys. Biological Psychiatry GOS. 3(1), p.68-77

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