Acetylcholine, Dopamine, and Glutamate measured in three brain areas with a new SPME-probe

Our new paper shows reliable Multi-Neuromodulator measurements in the awake nonhuman primate in prefrontal cortex, premotor cortex and the basal ganglia using a new chemical sensing probe. The probe uses principles of Solid-Phase-Microextraction and is a development by the SPME pioneer and collaborator Prof. Janusz Pawliszyn from the University of Waterloo. The paper can be downloaded here.

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Phase-specific Activation Induces Latent Connectivity Changes

A recent paper provides rare causal evidence that phase-specific stimulation during beta oscillation bursts lead to transient changes in effective (latent) connectivity. This finding and its potentially widespread implications are discussed in our paper Womelsdorf T, Hoffman K (2018) Latent Connectivity: Neuronal Oscillations Can Be Leveraged for Transient Plasticity. Current Biology. 28(16):R879-R882..

Theta and Beta Frequency

Theta and beta frequency range coherence between anterior cingulate cortex and frontal eye field indexes the successful preparation for anti-saccades and maintenance of working memory content – with larger ACC to FEF direction of granger causal information flow! These important findings is now published in Nature Communications by Sahand Babapoor-Farrokhran and Stefan Everling with contributions […]

Inter-areal neural routing states emerge and switch during oscillatory bursts and with attention

We have a new major finding published at Neuron. We found that spiking in different areas (ACC, Striatum, LPFC) engage in ~20ms wide correlations, and that this coordinated activity has systematic time lags that correspond to the anatomical connectivity. These ‘baseline routing states’ are amplified during beta bursts, and switch directionality (between ACC and PFC) […]