Acetylcholine, Dopamine, and Glutamate measured in three brain areas with a new SPME-probe

Our new paper shows reliable Multi-Neuromodulator measurements in the awake nonhuman primate in prefrontal cortex, premotor cortex and the basal ganglia using a new chemical sensing probe. The probe uses principles of Solid-Phase-Microextraction and is a development by the SPME pioneer and collaborator Prof. Janusz Pawliszyn from the University of Waterloo. The paper can be downloaded here.

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First Neuropharmacological Contribution

Congratulations to Ali and Mariann for the first neuropharmacological contribution from our laboratory with the article A computational psychiatry approach identifies how alpha-2A noradrenergic agonist Guanfacine affects feature-based reinforcement learning in the macaque . This study first surveys all 14 different tasks that have ever been used with Guanfacine in nonhuman primate studies and than […]

New Open-Source Experimental Suite for 3D experiments in monkeys, humans, and artificially intelligent agents

Our new open-source suite for experiments in virtual 3D environments is accepted at J Neurosci Methods and downloadable here. This suite is a complete software (using Unity3D) and hardware (using Arduinos) solution for conducting experiments in 3D environments. It allows running the same experiment in touchscreen, gaze control, or joystick mode (for humans and animals), […]

The phase of firing of fronto-striatal neurons encodes learning variables

Our new paper shows that neurons in the striatum, anterior cingulate and prefrontal cortex encode learning variables in the phase of firing. We outline a powerful regression based analysis pipeline that revealed spiking activity of neurons relative to the phase of beta oscillations carries significant learning information during reversal learning. The paper can be downloaded […]