Effective Connectivity Shows Asymmetries in Resonance and Latencies between Medial and Lateral Prefrontal Cortex Connections

The lab has a first article published about the strength, latency and resonance patterns of connections between the anterior cingulate cortex and lateral prefrontal cortex of the macaque. This work was led by postdoc Veronica Nacher and is published in Brain Structure and Function.
The paper identifies a novel electrical microstimulation protocol that can be used to map the efficacy of synaptic connections between distant brain structures.
We found that dACC stimulation-triggered evoked fields (EFPs) were more likely to be multiphasic in the lateral prefrontal cortex than in the reverse direction, with a large proportion of connections showing 2–4 inflection points resembling resonance in the 20–30 Hz beta frequency range. In addition we found that stimulation of dorsal anterior cingulate cortex (ACC) and lateral prefrontal cortex (lPFC) resulted, on average, in shorter-latency EFPs than lPFC → dACC. Overall, latencies and connectivity strength varied more than twofold depending on the precise anterior-to-posterior location of the connections. The Preprint pdf is linked here, the Brain Structure and Function pdf is linked here.

Related News

First Neuropharmacological Contribution

Congratulations to Ali and Mariann for the first neuropharmacological contribution from our laboratory with the article A computational psychiatry approach identifies how alpha-2A noradrenergic agonist Guanfacine affects feature-based reinforcement learning in the macaque . This study first surveys all 14 different tasks that have ever been used with Guanfacine in nonhuman primate studies and than […]

2017 E.W.R. Steacie Memorial Fellowship Award

What an honour and incredible acknowledgment of our research – Thilo received the 2017 E.W.R. Steacie Memorial Fellowship Award with five fellow scientists in Canada and across the Natural Sciences and Engineering. This is one of the most prestigious awards for young scientists in Canada, celebrating the critical role of fundamental, basic research for driving […]

Brain Day at Waterloo University

The 2015 BrainDay at Waterloo University hosted Thilo for a lecture for the neuroscience section. Brainday is a highly inspiring event organized by the Centre for Theoretical Neuroscience at Waterloo and the University to discuss brain topic from four different fields in a unifying daylong setting (Psychology, Philosophy, Systems Neuroscience, Theoretical Neuroscience). The talk at […]