What an honour and incredible acknowledgment of our research – Thilo received the 2017 E.W.R. Steacie Memorial Fellowship Award with five fellow scientists in Canada and across the Natural Sciences and Engineering. This is one of the most prestigious awards for young scientists in Canada, celebrating the critical role of fundamental, basic research for driving […]
We have new research out at PNAS about enhancing cognitive flexibility with highly selective allosteric modulation of the M1 muscarinic receptor (pdf: here)! Muscarinic receptors are known to mediate pro-cognitive effects of acetylcholine, but it has remained unclear whether they differentially affect the cognitive subfunctions of attentional filtering, set shifting, and learning. To clarify the […]
Acetylcholinergic Drug enhances attention at different dose as cognitive flexibilityWe tested how a cholinergic drug that is used to treat symptoms of dementia (donepezil, Arizept) affects cognitive abilities across multiple domains in monkeys. We found that donepezil showed stunning improvements of attentional filtering (less distraction) during visual search but at a different dose at it […]