We used focused ultrasound (FUS) sonication of the anterior cingualte and striatum to disrupt local processing during learning. FUS in ACC slowed down learning of atetntion sets – but only when the attentional demands were high and the task included the risk of loosing already attaiuned reward tokens. Under these cognitive and motivaitonally challenging conditions […]
We have a new major finding published at Neuron. We found that spiking in different areas (ACC, Striatum, LPFC) engage in ~20ms wide correlations, and that this coordinated activity has systematic time lags that correspond to the anatomical connectivity. These ‘baseline routing states’ are amplified during beta bursts, and switch directionality (between ACC and PFC) […]
We have new research out at PNAS about enhancing cognitive flexibility with highly selective allosteric modulation of the M1 muscarinic receptor (pdf: here)! Muscarinic receptors are known to mediate pro-cognitive effects of acetylcholine, but it has remained unclear whether they differentially affect the cognitive subfunctions of attentional filtering, set shifting, and learning. To clarify the […]
