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November 14, 2023

New Multi-task cognitive profiling platform for NHPs+humans

We published a new unity based software platform for profiling cognitive and motivational constructs in nonhuman primates and humans. The platform has multiple pre-configured tasks with some gamified features that makes them engaging to play for participants. Details are described and linked on the website: http://m-use.psy.vanderbilt.edu. The technical details are available in Watson et al. […]
October 19, 2023

Inter-areal neural routing states emerge and switch during oscillatory bursts and with attention

We have a new major finding published at Neuron. We found that spiking in different areas (ACC, Striatum, LPFC) engage in ~20ms wide correlations, and that this coordinated activity has systematic time lags that correspond to the anatomical connectivity. These ‘baseline routing states’ are amplified during beta bursts, and switch directionality (between ACC and PFC) […]
April 27, 2023

M1-selective allosteric modulation enhances cognitive flexibility

We have new research out at PNAS about enhancing cognitive flexibility with highly selective allosteric modulation of the M1 muscarinic receptor (pdf: here)! Muscarinic receptors are known to mediate pro-cognitive effects of acetylcholine, but it has remained unclear whether they differentially affect the cognitive subfunctions of attentional filtering, set shifting, and learning. To clarify the […]
January 23, 2023

Acetylcholinergic Drug enhances attention at different dose as cognitive flexibility

Acetylcholinergic Drug enhances attention at different dose as cognitive flexibilityWe tested how a cholinergic drug that is used to treat symptoms of dementia (donepezil, Arizept) affects cognitive abilities across multiple domains in monkeys. We found that donepezil showed stunning improvements of attentional filtering (less distraction) during visual search but at a different dose at it […]
September 15, 2022

ACC causally supports learning -difficult- attention sets

We used focused ultrasound (FUS) sonication of the anterior cingualte and striatum to disrupt local processing during learning. FUS in ACC slowed down learning of atetntion sets – but only when the attentional demands were high and the task included the risk of loosing already attaiuned reward tokens. Under these cognitive and motivaitonally challenging conditions […]

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